The central research question to be addressed in this paper is: what is the relationship between entangled political economy and public choice? Originating in the scholarly contributions of Richard E. Wagner, entangled political economy appears to maintain clear affinities with public choice theory, especially with regard to research topics and personnel. Despite those commonalities, our central proposition is that entangled political economy is sufficiently distinct from methodological and analytical dispositions predominating mainstream public choice theory. Contrasting mainstream public choice emphases upon utility-maximizing decisions by individuals, and equilibrating tendencies within political systems, entangled political economy embraces a broader range of motivations and outcomes corresponding with the presumption of open-endedness concerning political activity. This broader purview does not merely reflect the inclination of entangled political economy scholarship to utilize the analytical affordances of complexity and evolutionary economics, and the study of networks. Entangled political economy research provides opportunities to more meaningfully engage deeper questions surrounding rule-governed processes of political interaction. Within this, entangled political economy facilitates comparative institutional analysis of the collective learning capacities of varying political arrangements. In short, entangled political economy provides a viable pathway toward developing an epistemic political economy framework conducive to the realization of political orders consistent with underlying value commitments of liberty, justice, and equality.